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John Sheridan, Ph.D., Professor
Education
Undergraduate:
BS - Fordham University, 1972
Graduate:
MS - Rutgers University, 1974
Ph.D. - Rutgers University, 1976
Post
Doctoral Training:
Duke University
Appointments
Professor, Division of Oral Biology
The
George C. Paffenbarger Alumni-Endowed Chair in Dental Research
Professor, Department of Molecular Virology, Immunology, and
Medical Genetics
Faculty, Oral
Biology Graduate Program
Faculty, Neuroscience Graduate Studies Program
Associate Dean for Research
Associate Director, Institute for Behavioral Medicine Research
Contact Information
Office Address:
3143 Postle Hall
305 W.
12th Ave
Columbus, OH 43210
Office
Phone: (614) 688 4629
Lab
Phone: (614) 292 2012
Fax:
(614) 247 6945
Email:
sheridan.1@osu.edu
Affiliations &
Memberships
Member,
American Association for the Advancement of Science (AAAS)
Member, American Association of Immunologists (AAI)
Member, American Society for Microbiology (ASM)
Member, American Society for Virology (ASV)
Member, American Association for Dental Research (AADR)
Member, Society for Experimental Biology and Medicine (SEBM)
Member, Society for Leukocyte Biology (SLB)
Area of Expertise
Viral Immunology, Neuroendocrine Immunology and
Wound Healing
Teaching
Research Interests
Research Summary
Research in my lab is directed towards understanding the
pathways by which information from the central nervous system is
transmitted to the periphery and affects physiological
responses. Studies in the laboratory have defined a number of
cellular and molecular mechanisms by which environmental
factors, such as stress, affect the immune response. Recently,
using a model of social stress, my lab has shown that exposure
to repeated defeat, induces glucocorticoid resistance. Myeloid
cells in the spleen and liver of socially-stressed, subordinate
animals become insensitive to regulation by glucocorticoid
hormones. These studies have demonstrated the importance of the
hypothalamic-pituitary-adrenal axis and sympathetic nervous
system on innate and adaptive immune responses. This research
has been supported by the NIH (NIDCR, NIMH, NIA, NHBLI, and
NIAID), and the John D. and Catherine T. MacArthur Foundation.
Publications
Avitsur R, Kavelaars A, Heijnen C, Sheridan J.F. Social stress
and the regulation of tumor necrosis factor-alpha secretion.
Brain, Behavior Immunity 19:311-317, 2005.
Engler, H., Bailey, M.T., Engler, A., Stiner, L., Quan, N.,
Sheridan, J.F. Interleukin-1 receptor type 1-deficient mice fail
to develop social stress-associated glucocorticoid resistance in
the spleen. Psychoneuroendocrinology 33:108-117, 2008.
Bailey, M.T. Engler, H., Powell, N.D., Padgett, D.A., and J. F.
Sheridan Repeated social defeat increases bactericidal activity
of splenic macrophages through a Toll-like receptor-dependent
pathway. American Journal of Physiology; Regulatory,
Integrative, and Comparative Physiology 293: R1180-1190, 2007.
Bonneau RH, Padgett DA, Sheridan JF. Twenty years of
psychoneuroimmunology and viral infections in Brain, Behavior
and Kinsey SG, Bailey MT, Sheridan JF, Padgett DA, Avitsur R.
Repeated social defeat causes increased anxiety-like behavior
and alters splenocyte function in C57BL/6 and CD-1 mice. Brain
Behav Immun. 2007 May;21(4):458-66.
Kinsey, S. G., Bailey, M. T., Sheridan, J. F., Padgett, D. A.
The inflammatory response to social defeat is exaggerated in
aged mice. Physiology and Behavior 93:623-636, 2007.
Bailey M.T., Engler H., Sheridan J.F. Stress induces the
translocation of cutaneous and gastrointestinal microflora to
secondary lymphoid organs of C57BL/6 mice. J Neuroimmunol.
171:29-37, 2006.
Head, C.C., Farrow, M.J., Sheridan, J.F., and Padgett, D.A.
Androstenediol reduces the anti-inflammatory effects of
restraint stress during wound healing. Brain Behav Immun.
20:590-596, 2006
Bailey M.T., Engler H., Sheridan J.F. Stress induces the
translocation of cutaneous and gastrointestinal microflora to
secondary lymphoid organs of C57BL/6 mice. J Neuroimmunol. 2006
Feb;171(1-2):29-37.
Avitsur R., Hunzeker J., Sheridan J.F. Role of early stress in
the individual differences in host response to viral infection.
Brain, Behavior and Immunity 20:339-348, 2006.
Tseng, R., Padgett, D.A., Dhabhar, F., Engler, H. and Sheridan,
J.F. Stress-induced modulation of NK activity during influenza
viral infection: role of glucocorticoids and opioids. Brain,
Behavior and Immunity 19:153-164, 2005.
Engler, A., Roy, S., Sen, C., Padgett, D.A., and Sheridan, J.F.
Restraint stress alters lung gene expression in an experimental
influenza A viral infection. J. Neuroimmunology, 162:103-111,
2005.
Engler ,H., Engler, A., Bailey, M.T., J.F. Sheridan.
Tissue-specific alterations in the glucocorticoid sensitivity of
immune cells following repeated social defeat in mice. J.
Neuroimmunology 163:110-119, 2005.
Avitsur R, Kavelaars A, Heijnen C, Sheridan J.F. Social stress
and the regulation of tumor necrosis factor-alpha secretion.
Brain, Behavior Immunity 19:311-317, 2005.Immunity. Brain Behav
Immun. 2007 Mar;21(3):273-80.
Book Chapters
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